Dawn Odom, an RTI-HS Research Statistician, will participate in the Biopharmaceutical Section on Health Policy Statistics at the upcoming Denver Joint Statistical Meetings. Dawn’s talk is titled “Meta-Regression of Placebo Response” and the presentation was developed with RTI-HS co-authors Jianmin Wang, Research Statistician, and Bill Irish, Global Head of Biostatistics. The talk will beheld August 6th at 2:50. The abstract follows:
In traditional meta-analysis and by extension meta-regression, treatment effect sizes (e.g., odds ratio, relative risk) are often estimated using a model with random effects to account for heterogeneity between studies. In a direct comparison, meta-regression typically examines the relative effect of treatment versus placebo while controlling for study-level or treatment-level predictors. However, it may be of interest to estimate the expected placebo response to establish a more reliable reference value. This study will demonstrate our modifications to the standard meta-regression approach and present findings based on a literature review of clinical trials.
To learn more about the conference, please the
JSM website. If you plan to attend the conference and would like to speak with Dawn, please
email her directly.