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2003

Allen, R.M., A.L. Granger, and L.A. Dykstra. (2003). "The competitive N-methyl-D-aspartate receptor antagonist (-)-6-phosphonomethyl-deca-hydroisoquinoline-3-carboxylic acid (LY235959) potentiates the antinociceptive effects of opioids that vary in efficacy at the mu-opioid receptor." Journal of Pharmacology and Experimental Therapeutics, 307(2):785-792.

(-)-6-Phosphonomethyl-deca-hydroisoquinoline-3-carboxylic acid (LY235959) is a competitive N-methyl-D-aspartate receptor antagonist shown to prevent the development of tolerance to the... Full Abstract »

Wenham, R.M., J.M. Schildkraut, K. McLean, B. Calingaert, R.C. Bentley, J. Marks, and A. Berchuck. (2003). "Polymorphisms in BRCA1 and BRCA2 and risk of epithelial ovarian cancer." Clinical Cancer Research, 9(12):4396-4403.

Purpose: Because inherited BRCA1or BRCA2 mutations strikingly increase ovarian cancer risk, polymorphisms in these genes could represent low penetrance susceptibility alleles. Previous studies of... Full Abstract »

Wenham, R.M., B. Calingaert, S. Ali, K. McClean, R. Whitaker, R. Bentley, J.M. Lancaster, J. Schildkraut, J. Marks, and A. Berchuck. (2003). "Matrix metalloproteinase-1 gene promoter polymorphism and risk of ovarian cancer." Journal of the Society for Gynecologic Investigation, 10(6):381-387.

OBJECTIVE: It has been suggested that the 2G allele of a guanine insertion-deletion promoter polymorphism in the promoter of the matrix metalloproteinase-1 (MMP1) gene may increase susceptibility to... Full Abstract »

Miller, D.P., D. Neuberg, V. de, J.C. Wain, T.J. Lynch, L. Su, and D.C. Christiani. (2003). "Smoking and the risk of lung cancer: susceptibility with GSTP1 polymorphisms." Epidemiology, 14(5):545-551.

BACKGROUND: GSTP1 is a gene that helps detoxify foreign substances in the body. Functional polymorphisms of GSTP1 have been studied as risk factors for lung cancer. Past studies have compared the... Full Abstract »

Abraham, B., J.M. Anto, E. Barreiro, E.H.D. Bel, G. Bonsignore, J. Bousquet, J. Castellsague, P. Chanez, F. Cibella, G. Cuttitta, B. Dahlen, S.E. Dahlen, N. Drews, R. Djukanovic, L.M. Fabbri, G. Folkerts, M. Gaga, C. Gratziou, G. Guerrera, S.T. Holgate, P.H. Howarth, S.L. Johnston, F. Kanniess, J.C. Kips, H.A.M. Kerstjens, M. Kumlin, H. Magnussen, F.P. Nijkamp, N. Papageorgiou, A. Papi, D.S. Postma, R.A. Pauwels, K.F. Rabe, K. Richter, A.C. Roldaan, M. Romagnoli, A. Roquet, C. Sanjuas, N.M. Siafakas, W. Timens, N. Tzanakis, I. Vachier, A.M. Vignola, L. Watson, G. Yourgioti, and The ENFUMOSA Study Group. (2003). "The ENFUMOSA cross-sectional European multicentre study of the clinical phenotype of chronic severe asthma." European Respiratory Journal, 22(3):470-477.

Since severe asthma is a poorly understood, major health problem, 12 clinical specialist centres in nine European countries formed a European Network For Understanding Mechanisms Of Severe Asthma... Full Abstract »

Cain, V.S., C.B. Johannes, N.E. Avis, B. Mohr, M. Schocken, J. Skurnick, and M. Ory. (2003). "Sexual functioning and practices in a multi-ethnic study of midlife women: Baseline results from SWAN.." Journal of Sex Research, 40(3):266-276.

This study examined the sexual practices and function of midlife women by ethnicity (African American, Caucasian, Chinese, Hispanic, Japanese) and menopausal status. Sexual behavior was compared in... Full Abstract »

Vine, M.F., B. Calingaert, A. Berchuck, and J.M. Schildkraut. (2003). "Characterization of prediagnostic symptoms among primary epithelial ovarian cancer cases and controls." Gynecologic Oncology, 90(1):75-82.

Objective The goal of this study was to characterize types, frequency, combinations, and relative onset of symptoms among ovarian cancer cases and controls. Methods Participants were from an... Full Abstract »

Glick, H.A., S.M. Orzol, J.F. Tooley, D. Polsky, and J.A. Mauskopf. (2003). "Design and analysis of unit cost estimation studies: How many hospital diagnoses? How many countries?." Health Economics, 12(7):517-527.

We evaluated three questions that commonly arise when unit costing exercises for multinational trials are conducted: (1). In countries where investigators plan to collect hospital unit cost... Full Abstract »

LoRusso, P.M., R.S. Herbst, D. Rischin, M. Ranson, H. Calvert, E. Raymond, D. Kieback, S. Kaye, L. Gianni, A. Harris , T. Bjork, A. Maddox, M.L. Rothenberg, E.J. Small, E.H. Rubin, A. Feyereislova, A. Heyes, S.D. Averbuch, J. Ochs, and J. Baselga. (2003). "Improvements in quality of life and disease-related symptoms in phase I trials of the selective oral epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 in non-small cell lung cancer and other solid tumors." Clinical Cancer Research, 9(6):2040-2048.

Purpose: The feasibility and utility of assessing quality of life (QoL) and disease-related symptoms in patients with advanced cancer have been evaluated in two Phase I clinical trials of p.o.... Full Abstract »

Su, L., Y. Sai, R. Fan, S.W. Thurston, D.P. Miller, W. Zhou, J.C. Wain, T.J. Lynch, G. Liu, and D.C. Christiani. (2003). "P53 (codon 72) and P21 (codon 31) polymorphisms alter in vivo mRNA expression of p21." Lung Cancer, 40(3):259-266.

p21 (Waf1/Cip1) is a downstream target of p53. We evaluated the association between p21 polymorphism (codon 31), p53 polymorphism (codon 72) and their corresponding in vivo mRNA expression. In this... Full Abstract »

Miller, D.P., V. de, D. Neuberg, J.C. Wain, T.J. Lynch, L. Su, and D.C. Christiani. (2003). "Association between self-reported environmental tobacco smoke exposure and lung cancer: modification by GSTP1 polymorphism." International Journal of Cancer, 104(6):758-763.

Environmental Tobacco Smoke (ETS) exposure has been associated with lung cancer risk. ETS is composed of emissions from cigarette smoke and contains a higher concentration of tobacco smoke... Full Abstract »

Morrell, M.J., J. Isojarvi, A.E. Taylor, M. Dam, R. Ayala, G. Gomez, F. O'Neill, P. Tennis, and J. Messenheimer. (2003). "Higher androgens and weight gain with valproate compared with lamotrigine for epilepsy." Epilepsy Research , 54(2-3):189-199.

BACKGROUND: Valproate is used widely for the treatment of epilepsy but has been associated with hyperandrogenism, hyperinsulinemia, and dyslipidemia. The mechanism for these associations is unknown,... Full Abstract »

Case, C.C., T.A. Jacobson, S. Roberts, A. Buckley, K.M. Murtaugh, J.C.Y. Sung, D. Gause, C. Varas, and C.M. Ballantyne. (2003). "Management of persons with high risk of coronary heart disease but low serum low-density lipoprotein cholesterol." American Journal of Cardiology, 91(9):1134-1136.

Ackerman, S.J., M. Mordin, J. Reblando, X. Xu, J. Schein, S. Vallow, and M. Brennan. (2003). "Patient-reported utilization patterns of fentanyl transdermal system and oxycodone hydrochloride controlled-release among patients with chronic nonmalignant pain." Journal of Managed Care Pharmacy, 9(3):223-231.

BACKGROUND: Although use of long-acting opioid analgesics has increased for chronic nonmalignant pain management, little is known about patient-reported utilization patterns. OBJECTIVE: To assess... Full Abstract »

Rothman, K.J., D.P. Funch, T. Alfredson, J. Brady, and N.A. Dreyer. (2003). "Randomized field trial of vaginal douching, pelvic inflammatory disease and pregnancy." Epidemiology, 14(3):340-348.

Background. Several case-control studies have reported that women who use vaginal douche products are at increased risk for pelvic inflammatory disease. Women who douche regularly may do so for... Full Abstract »

Thieda, P., S. Beard, A. Richter, and J. Kane. (2003). "An economic review of compliance with medication therapy in the treatment of schizophrenia." Psychiatric Services, 54(4):508-516.

Objectives: The authors examined published economic evaluations of schizophrenia and antipsychotic therapies to determine the role of compliance with medication therapy in the economic cost of... Full Abstract »

Iida, M., C.H. Anna, J. Hartis, M. Bruno, B. Wetmore, J.R. Dubin, S. Sieber, L. Bennett, M.L. Cunningham, R.S. Paules, K.B. Tomer, C.D. Houle, A.B. Merrick, R.C. Sills, and T.R. Devereux. (2003). "Changes in global gene and protein expression during early mouse liver carcinogenesis induced by non-genotoxic model carcinogens oxazepam and Wyeth-14,643." Carcinogenesis, 24(4):757-770.

We hypothesized that the mouse liver tumor response to non-genotoxic carcinogens would involve some common early gene and protein expression changes that could ultimately be used to predict chemical... Full Abstract »

Zhou, W., G. Liu, D.P. Miller, S.W. Thurston, L.L. Xu, J.C. Wain, T.J. Lynch, L. Su, and D.C. Christiani. (2003). "Polymorphisms in the DNA repair genes XRCC1 and ERCC2, smoking, and lung cancer risk." Cancer Epidemiology, Biomarkers and Prevention, 12(4):359-365.

XRCC1 (X-ray cross-complementing group 1) and ERCC2 (excision repair cross-complementing group 2) are two major DNA repair proteins. Polymorphisms of these two genes have been associated with... Full Abstract »

Pattanayak, S.K., D.E. Mercer, E. Sills, and J.C. Yang. (2003). "Taking stock of agroforestry adoption studies." Agroforestry Systems, 57(3):173-186.

In light of the large number of empirical studies of agroforestry adoption published during the last decade, we believe it is time to take stock and identify general determinants of agroforestry... Full Abstract »

Andrews, E.B., and S. Eaton. (2003). "Additional considerations in longitudinal database research." Value in Health, 6(2):85-87.

Displaying 981 through 1000 of 1537 items.

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